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Conference ·
Predicting PIRA in clinical trials and observational studies
A focused examination of how progression independent of relapse activity can be defined and predicted.
MAGNIMS · Verona, Italy
- Delivered
- Event
- MAGNIMS
- Place
- Verona, Italy
- Format
- Conference
- Source deck
- 22 slides
From the slides
Deck notes
This MAGNIMS presentation examined progression independent of relapse activity across trials and observational studies. It focused on the practical choices that shape an individual prediction.
The question
Can PIRA be predicted for an individual when its definition depends on outcome measures, follow-up and the choice of time zero?
Deck outline
- PIRA as a clinical and trial outcome
- Evidence from clinical trials
- Moving from group effects to individual prediction
- Statistical framing and model groups
- EDSS limitations and the definition of time zero
- Intention-to-treat and decentralised approaches
Take-away
Individual PIRA prediction depends as much on a precise outcome definition and study design as it does on the modelling method.