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Clinical prediction using complex models

A measured look at where complex models can improve multiple sclerosis prediction and where complexity can obscure understanding.

ECTRIMS 2022

A web sketch of the deck’s central idea
Delivered
Event
ECTRIMS 2022
Format
Conference
Source deck
23 slides

From the slides

Deck notes

This ECTRIMS talk considered the role of complex models in clinical prediction. It moved from simple relationships to personalised risk, MRI-derived subtypes and emerging outcomes.

The question

Where does model complexity add clinical value, and when does it make a prediction harder to understand or use?

Deck outline

  • Relationships, models and clinical questions
  • Where predictive models may help
  • Disease activity and phenotypic conversion
  • Personalised disability risk
  • MRI-derived multiple sclerosis subtypes
  • Emerging outcomes and future perspectives

Take-away

Complexity is useful when it improves a defined clinical decision; the model still needs an outcome and explanation that clinicians can assess.